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Registros recuperados: 10
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Acute and chronic toxicity of the benzodiazepine diazepam to the tropical crustacean Mysidopsis juniae Anais da ABC (AABC)
SILVA,ALLYSON Q. DA; NILIN,JEAMYLLE; LOUREIRO,SUSANA; COSTA-LOTUFO,LETICIA V..
Abstract Pharmaceuticals occur in the environment due to their excessive consumption and the inefficiency of treatment plants to degrade, inactivate or remove them. Diazepam (DZP) stands out as the most consumed benzodiazepine, and induces sedative effects and reduces anxiety. Considering its potential appearance in several environmental compartments, the aim of the present study was to determine the effects of DZP under acute and chronic exposures on the mysid Mysidopsis juniae. Mortality was assessed using an acute toxicity test and a LC50 of 3.7 ± 0.5 mg·L-1was derived. The mass and length of the mysids was recorded in the chronic exposure to test for sublethal effects, and concentrations of 0.25 and 0.5 mg·L-1 of DZP affected mysids length and dry...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Emerging contaminants; Mysids; Sublethal effects; Pharmaceuticals.
Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000100713
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Analysis of Scientific Research Driving Microalgae Market Opportunities in Europe ArchiMer
Rumin, Judith; Nicolau, Elodie; Junior, Raimundo Gonçalves De Oliveira; Fuentes-grünewald, Claudio; Picot, Laurent.
A bibliographic database of scientific papers published by authors affiliated to research institutions worldwide, especially focused in Europe and in the European Atlantic Area, and containing the keywords “microalga(e)” or “phytoplankton” was built. A corpus of 79,020 publications was obtained and analyzed using the Orbit Intellixir software to characterize the research trends related to microalgae markets, markets opportunities and technologies that could have important impacts on markets evolution. Six major markets opportunities, the production of biofuels, bioplastics, biofertilizers, nutraceuticals, pharmaceuticals and cosmetics, and two fast-evolving technological domains driving markets evolution, microalgae harvesting and extraction technologies...
Tipo: Text Palavras-chave: Bibliometric; Microalgae; Biofertilizers; Bioplastics; Biotechnology; Cosmetics; Europe; Food; GMO; Market; Nutraceuticals; Pharmaceuticals; Research.
Ano: 2020 URL: https://archimer.ifremer.fr/doc/00630/74185/73788.pdf
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Contamination de moules (Mytilus sp.) en milieu marin par des substances pharmaceutiques et produits de soin ArchiMer
Bachelot, Morgane.
Pharmaceutical and personal care products used for human health protection are detected in all aquatic ecosystems. Among them, some compounds have physico-chemical or pharmacological caracteristics that suggest a bioaccumulation capability. It’s the case of the UV filters, EHMC and OC, with log Kow higher than 5 or pharmaceuticals like diazepam and tetrazepam, with log Kow higher than 2.82. The aim of these Phd works was to assess marine mussels contamination for UV filters and benzodiazepines. So, a new analytical method was developed and validated for the determination of these compounds in mussels. EHMC and OC analysis realized in mussels sampled in french coastal waters showed that mainly contamination came from recreational activities in summer...
Tipo: Text Palavras-chave: Benzodiazépines; Filtres UV; Médicaments; Moules; Contamination marine; Surveillance des eaux côtières; Benzodiazepine; UV filters; Pharmaceuticals; Mussels; Marine contamination; Coastal water monitoring.
Ano: 2010 URL: http://archimer.ifremer.fr/doc/00011/12259/9028.pdf
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Contamination des milieux aquatiques par les substances pharmaceutiques et cosmétiques - Etat des lieux et perspectives ArchiMer
Collette-bregand, Maude; James, Alice; Munshy, Catherine; Bocquene, Gilles.
This document reports a survey of the aquatic contamination by cosmetics and medicinal products for human and veterinary uses. The contamination of the continental, estuary and coastal waters by these substances gives rise to questions on environmental risk assessment and management. Among the pharmaceutical classes involved, substances such as anti-inflammatory drugs, steroid hormones, antibiotics and hypolipemiants are of particular concern. Present regulations do not take into account the medical effluents in the environment. A significant part of these substances is not destroyed in water treatment plants whereas veterinary substances are directly spread in the environment. Some molecules occur in particularly high concentrations as shown for...
Tipo: Text Palavras-chave: Médicaments; Produits pharmaceutiques; Vétérinaires; Cosmétiques; Émergents; Évaluation du risque environnemental; Risque chimique; Milieu marin; Pharmaceuticals; Ecotoxicity; Environmental risk assessment; Prioritization methods; Endocrine disruptors; Sewage; Sea water.
Ano: 2009 URL: http://archimer.ifremer.fr/doc/00066/17773/15295.pdf
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Determination of olanzapine by spectrophotometry using permanganate BJPS
Rajendraprasad,Nagaraju; Basavaiah,Kanakapura.
Two new spectrophotometric methods using permanganate as the oxidimetric reagent for the determination of olanzapine (OLP) were developed and validated as per the current ICH guidelines. The methods involved the addition of known excess of permanganate to OLP in either acid or alkaline medium followed by the determination of unreacted permanganate at 550 nm (method A) or bluish-green color of manganate at 610 nm (method B). The decrease in absorbance in method A or increase in absorbance in method B as a function of concentration of OLP was measured and related to OLP concentration. Under optimized conditions, Beer's law was obeyed over the ranges 2.0 to 20 and 1.0 to 10 μg mL-1 in method A and method B, respectively. The calculated molar absorptivity...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Olanzapine/determination; Spectrophotometry; Permanganate; Pharmaceuticals.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000300020
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INTELLECTUAL PROPERTY RIGHTS AND TRADE: ANALYSIS OF BIOLOGICAL PRODUCTS, MEDICINALS AND BOTANICALS, AND PHARMACEUTICALS AgEcon
Smith, Pamela J..
We examine the impact of intellectual property rights (IPRs) on US exports of biological, medicinal, botanical, and pharmaceutical products. We find that: (1) strong IPRs enhance monopoly power of US exports in countries with weak imitative abilities; and (2) strong IPRs expand markets for US exports in countries with strong imitative abilities.
Tipo: Conference Paper or Presentation Palavras-chave: Intellectual property rights; Exports; Biotechnologies; Medicinals; Botanicals; Pharmaceuticals; International Relations/Trade; Research and Development/Tech Change/Emerging Technologies; F10; F13; Q16; Q17; K55; O34.
Ano: 1999 URL: http://purl.umn.edu/21525
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Novel Pharmaceuticals from Kenyan Marine Cyanobacteria OceanDocs
Dzeha, T..
Two projects undertaken at the Heriot-Watt University, Edinburgh, U.K as part of the WIOMSA Marg II Programme are presented here. Project 1 was on studies carried out on the Kenyan marine cyanobacterium Lyngbya majuscula, which was collected from Shimoni, 100 km south of Mombasa, Kenya and ferried to the U.K on 12th October 2003. Specifically, L. majuscula was investigated on the potential for bioprocess intensified production of secondary metabolites with therapeutic potential, the Chemistry of its secondary metabolites and that of the cultures, and on the 16S rDNA classification of its epiphytic bacteria isolates. Project 2 focused on the isolation of cell-cell signaling inducer compounds from biofilms of marine bacteria Bacillus licheniformis EI-34-6.
Tipo: Report Palavras-chave: Pharmaceuticals; Aquatic plants; Medical plants Bacteria Pharmaceutical products Bacteria Pharmaceutical plants http://aims.fao.org/aos/agrovoc/c_765 http://aims.fao.org/aos/agrovoc/c_13278.
Ano: 2004 URL: http://hdl.handle.net/1834/1291
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Producing recombinant commercial proteins ArchiMer
Cadoret, Jean-paul; Bardor, M; Lerouge, P; Cabigliera, M; Henriquez, Vitalia; Carlier, Aude.
Extraction of natural substances and chemical synthesis are the main sources of pharmaceutical molecules. When possible, one may transfer the gene of the molecule in living cells creating individual factories producing on demand and in a safe way the requested molecule. Today, bacteria, yeast, mammalian cells and plants constitute the main plate-forms for various commercial products. Microalgae present numerous advantages and could offer a powerful tool for the production of commercial molecules in a near future.
Tipo: Text Palavras-chave: Genetics; Recombinant; Algae; Pharmaceuticals; Gene transfer; Biotechnology; Génétique; Recombinant; Algues; Pharmaceutique; Transfert de gène; Biotechnologie.
Ano: 2008 URL: http://archimer.ifremer.fr/doc/2008/publication-4045.pdf
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Sensitive and rapid titrimetric and spectrophotometric methods for the determination of stavudine in pharmaceuticals using bromate-bromide and three dyes Anais da ABC (AABC)
Basavaiah,Kanakapura; Ramakrishna,Veeraiah; Somashekar,Chikkaswamy; Kumar,Urdigere R. Anil.
Four sensitive and rapid methods for the determination of stavudine (STV) in bulk drug and in dosage forms were developed and optimized. In titrimetry, aqueous solution of STV was treated with a known excess of bromate-bromide in HCl medium followed by estimation of unreacted bromine by iodometric back titration. Spectrophotometric methods involve the addition of a measured excess of bromate-bromide in HCl medium and subsequent estimation of the residual bromine by reacting with a fixed amount of methyl orange, indigocarmine or thymol blue followed by measurement of absorbance at 520 nm (method A), 610 nm (method B) or 550 nm (method C). In all the methods, the amount of bromate reacted corresponds to the amount of STV. Calculations in titrimetry were...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Stavudine determination; Titrimetry; Spectrophotometry; Bromate-bromide; Dyes; Pharmaceuticals.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652008000200003
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Toxicity assessment of five emerging pollutants, alone and in binary or ternary mixtures, towards three aquatic organisms ArchiMer
Di Poi, Carole; Costil, Katherine; Bouchart, Valerie; Halm-lemeille, Marie-pierre.
Despite a growing scientific attention on ecological impact of emerging pollutants (EPs) such as pharmaceuticals, personal care products, and pesticides, knowledge gaps remain regarding mixture toxicity and effects on aquatic organisms. Several EPs were screened in seawater (Normandy, France), and the ecotoxicity of five compounds, chosen on their occurrence in ecosystems and use worldwide, was assessed and were the biocides methylparaben (MP) and triclosan (TCS), a pesticide degradation product (AMPA), and the pharmaceuticals venlafaxine (VEN) and carbamazepine (CBZ). The acute or sub-chronic toxicity, alone or in binary/ternary mixtures of three of them (CBZ, AMPA, and MP), was assessed on one marine and two freshwater organisms: Crassostrea gigas,...
Tipo: Text Palavras-chave: Pharmaceuticals; Personal care products; Pesticides; Mixture and single-compound toxicity; Freshwater species; Marine bivalve.
Ano: 2018 URL: https://archimer.ifremer.fr/doc/00389/50004/52260.pdf
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